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  1. Kosonocky CW, Wilke CO, Marcotte EM, Ellington AD, Mining Patents with Large Language Models Demonstrates Congruence of Functional Labels and Chemical Structures, Digital Discovery, : (2024) PubMed Link arXiv preprint (deposited Sept 15, 2023)
  2. Lee M, Guo Q, Kim M, Choi J, Segura A, Genceroglu A, LeBlanc L, Ramirez N, Jang YJ, Jang Y, Lee BK, Marcotte EM, Kim J, Systematic mapping of TF-mediated cell fate changes by a pooled induction coupled with scRNA-seq and multi-omics approaches, Genome Research, 34:1–14 (2024) PubMed Link PDF
  3. Orengo C, Ehrenreich IM, Marcotte EM, Kolodny R, Ben-Tal N, de Boer CG, McWhite CD, Ranganathan R, Honig B, Bromberg Y, Thornton JW, What can recent methodological advances help us understand about protein and genome evolution?, Cell Systems, 15(3):205-210 (2024) PubMed Link PDF
  4. Palukuri MV, Marcotte EM, DeepSLICEM: Clustering CryoEM particles using deep image and similarity graph representations, bioRxiv, Deposited Feb 8: (2024) PubMed Link
  5. Leggere J, Hibbard J, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB, Label-free proteomic comparison reveals ciliary and non- ciliary phenotypes of IFT-A mutants, Molecular Biology of the Cell, Jan 3:mbcE23030084 (2024) PubMed Link bioRxiv preprint (deposited Mar 9, 2023)


  1. Goike J, Hsieh CL, Horton AP, Gardner EC, Zhou L, Bartzoka F, Wang N, Javanmardi K, Herbert A, Abbassi S, Xie X, Xia H, Shi PY, Renberg R, Segall-Shapiro TH, Terrace CI, Wu W, Shroff R, Byrom M, Ellington AD, Marcotte EM, Musser JM, Kuchipudi SV, Kapur V, Georgiou G, Weaver SC, Dye JM, Boutz DR, McLellan JS, Gollihar JD, SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode, Communications Biology, 6(1):1250 (2023) PubMed Link PDF
  2. Mapes JH, Stover J, Stout HD, Folsom TM, Babcock E, Loudwig S, Martin C, Austin MJ, Tu F, Howdieshell CJ, Simpson ZB, Blom T, Weaver D, Winkler D, Vander Velden K, Ossareh PM, Beierle JM, Somekh T, Bardo AM, Anslyn EV, Marcotte EM, Swaminathan J, Robust and scalable single-molecule protein sequencing with fluorosequencing, bioRxiv, Deposited Sept 16: (2023) PubMed Link
  3. Garge RK, Geck RC, Armstrong JO, Dunn B, Boutz DR, Battenhouse A, Leutert M, Dang V, Jiang P, Kwiatkowski D, Peiser T, McElroy H, Marcotte EM, Dunham MJ, Systematic Profiling of Ale Yeast Protein Dynamics across Fermentation and Repitching, G3, :jkad293 (2023) PubMed Link bioRxiv preprint (deposited Sept 22, 2023)
  4. Smith MB, VanderVelden K, Blom T, Stout HD, Mapes JH, Folsom TM, Martin C, Bardo AM, Marcotte EM, Estimating error rates for single molecule protein sequencing experiments, bioRxiv, Deposited July 19: (2023) PubMed Link
  5. McCafferty CL, Papoulas O, Lee C, Bui KH, Taylor DW, Marcotte EM, Wallingford JB, An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexes, bioRxiv, Deposited July 10: (2023) PubMed Link
  6. Ghanaeian A, Majhi S, McCafferty CL, Nami B, Black CS, Yang SK, Legal T, Papoulas O, Janowska M, Valente-Paterno M, Marcotte EM, Wloga D, Bui KH, Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism, Nature Communications, 14:5741 (2023) PubMed Link PDF bioRxiv preprint (deposited June 01, 2023)
  7. Moreno RY, Juetten KJ, Panina SB, Butalewicz JP, Floyd BM, Ramani MKV, Marcotte EM, Brodbelt JS, Zhang Yan, Distinctive interactomes of RNA polymerase II phosphorylation during different stages of transcription, iScience, 26(9):107581 (2023) PubMed Link PDF SSRN preprint (deposited May 17, 2023)
  8. Kubo S, Black CS, Joachimiak E, Yang SK, Legal T, Peri K, Khalifa AAZ, Ghanaeian A, McCafferty CL, Valente-Paterno M, De Bellis C, Huynh PM, Fan Z, Marcotte EM, Wloga D, Bui KH, Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins, Nature Communications, 14:Article number: 2168 (2023) PubMed Link PDF
  9. McCafferty CL, Pennington EL, Papoulas O, Taylor DW, Marcotte EM, Does AlphaFold2 model proteins' intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins, Communications Biology, 6:Article number: 421 (2023) PubMed Link PDF bioRxiv preprint (deposited Aug 26, 2022)
  10. June V, Xu D, Papoulas O, Boutz D, Marcotte EM, Chen ZJ, Protein nonadditive expression and solubility contribute to heterosis in Arabidopsis hybrids and allotetraploids, Frontiers in Plant Science, 14:1252564 (2023) PubMed Link PDF bioRxiv preprint (deposited Mar 2, 2023)


  1. Mulvihill CJ, Lutgens J, Gollihar JD, Bachanová P, Marcotte EM, Ellington AD, Gardner EC, Humanized CB1R and CB2R yeast biosensors enable facile screening of cannabinoid compounds, bioRxiv, Deposited Oct 12: (2022) PubMed Link
  2. Smith MB, Simpson ZB, Marcotte EM, Amino acid sequence assignment from single molecule peptide sequencing data using a two-stage classifier, PLoS Computational Biology, 19(5):e1011157 (2023) PubMed Link PDF bioRxiv preprint (deposited Sept 26, 2022)
  3. McWhite CD, Sae-Lee W, Yuan Y, Mallam A, Gort-Frietas NA, Ramundo S, Onishi M, Marcotte EM, Alternative proteoforms and proteoform-dependent assemblies in humans and plants, bioRxiv, Deposited Sept 22: (2022) PubMed Link
  4. Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy G, Drew K, Emili A, Taylor DW, Marcotte EM, The protein organization of a red blood cell, Cell Reports, 40(3):111103 (2022) PubMed Link PDF bioRxiv preprint (deposited Dec 11, 2021)
  5. McCafferty CL, Papoulas O, Jordan MA, Hoogerbrugge G, Nichols C, Pigino G, Taylor DW, Wallingford JB, Marcotte EM, Integrative modeling reveals the molecular architecture of the Intraflagellar Transport A (IFT-A) complex, eLife, 11:e81977 (2022) PubMed Link PDF bioRxiv preprint (deposited Jul 5, 2022)
  6. Abdullah M, Greco BM, Laurent JM, Garge RK, Boutz DR, Vandeloo M, Marcotte EM, Kachroo AH, Rapid, scalable, combinatorial genome engineering by Marker-less Enrichment and Recombination of Genetically Engineered loci (MERGE), Cell Reports Methods, 3:100464 (2023) PubMed Link PDF bioRxiv preprint (deposited Jun 21, 2022) Supplement
  7. Palukuri MV, Patil RS, Marcotte EM, Molecular complex detection in protein interaction networks through reinforcement learning, BMC Bioinformatics, 24:306 (2023) PubMed Link bioRxiv preprint (deposited Jun 21, 2022) pdf available here
  8. Bachman JL, Wight CD, Bardo AM, Johnson AM, Pavlich CI, Boley AJ, Wagner HR, Swaminathan J, Iverson BL, Marcotte EM, Anslyn EV, Evaluating the Effect of Dye–Dye Interactions of Xanthene-Based Fluorophores in the Fluorosequencing of Peptides, Bioconjugate Chemistry, 33(6):1156-1165 (2022) PubMed Link PDF
  9. Kustatscher G, Collins T, Gingras AC, Guo T, Hermjakob H, Ideker T, Lilley KS, Lundberg E, Marcotte EM, Ralser M, Rappsilber R, An invitation to help define the challenge and goals for an understudied proteins initiative, Nature Biotechnology, 40(6):815-817 (2022) PubMed Link PDF
  10. Huebner RJ, Weng S, Lee C, Sarıkaya S, Papoulas O, Cox RM, Marcotte EM, Wallingford JB, ARVCF catenin controls force production during vertebrate convergent extension, Developmental Cell, 57:1-13 (2022) PubMed Link PDF bioRxiv preprint (deposited June 22, 2021, under the title Cell adhesions link subcellular actomyosin dynamics to tissue scale force production during vertebrate convergent extension)
    DevCellHuebnerCover 2022b.jpg
  11. Kustatscher G, Collins T, Gingras AC, Guo T, Hermjakob H, Ideker T, Lilley KS, Lundberg E, Marcotte EM, Ralser M, Rappsilber R, Understudied proteins: Opportunities and challenges for functional proteomics, Nature Methods, 19:774–779 (2022) PubMed Link PDF
  12. Floyd BM, Marcotte EM, Protein sequencing, one molecule at a time, Annual Review of Biophysics, 51:181-200 (2022) PubMed Link PDF Author's free reprint access link


  1. Hinson CM, Bardo AM, Shannon CE, Rivera S, Swaminathan J, Marcotte EM, Anslyn EV, Studies of Surface Preparation for the Fluorosequencing of Peptides, Langmuir, 37(51):14856–14865 (2021) PubMed Link PDF
  2. Kim CY, Baek S, Cha J, Yang S, Kim E, Marcotte EM, Hart T, Lee I, HumanNet v3: an improved database of human gene networks for disease research, Nucleic Acids Res, Nov 8:gkab1048: (2021) PubMed Link PDF
  3. Zhang L, Floyd BM, Chilamari M, Mapes J, Swaminathan J, Bloom S, Marcotte EM, Anslyn EV, Photoredox-catalyzed decarboxylative C-terminal differentiation for bulk and single molecule proteomics, ACS Chem Biol, 16:2595−2603 (2021) PubMed Link PDF bioRxiv preprint (deposited July 9, 2021)
  4. Palukuri MV, Marcotte EM, Super.Complex: A supervised machine learning pipeline for molecular complex detection in protein-interaction networks, PLoS One, 16(12):e0262056 (2021) PubMed Link PDF bioRxiv preprint (deposited October 11, 2021)
  5. Garge RK, Cha HJ, Lee, C, Gollihar JD, Kachroo AH, Wallingford JB, Marcotte EM, Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast, Genetics, 219(1):iyab101 (2021) PubMed Link PDF bioRxiv preprint (deposited Sept 15, 2020 under the title Antifungal benzimidazoles disrupt vasculature by targeting one of nine β-tubulins) Commentary
  6. Bean BDM, Mulvihill C, Garge RK, Boutz DR, Rousseau O, Floyd BM, Cheney W, Gardner EC, Ellington AD, Marcotte EM, Gollihar JD, Whiteway M, Martin VJJ, Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols, Nature Communications, 13(1):2882 (2022) PubMed PDF bioRxiv preprint (deposited May 14, 2021)
  7. Alfaro J, Bohländer P, Dai M, Filius M, Howard CJ, van Kooten XF, Ohayon S, Pomorski A, Schmid S, Aksimentiev A, Anslyn EV, Bedran G, Chan C, Chinappi M, Coyaud E, Dekker C, Dittmar G, Drachman N, Eelkema R, Goodlett D, Hentz S, Kalathiya U, Kelleher NL, Kelly RT, Kelman Z, Kim SH, Kuster B, Rodriguez-Larrea D, Lindsey S, Maglia G, Marcotte EM, Marino JP, Masselon C, Mayer M, Samaras P, Sarthak K, Sepiashvili L, Stein D, Wanunu M, Wilhelm M, Yin P, Meller A, Joo C, The emerging landscape of single-molecule protein sequencing technologies, Nature Methods, 18(6):604-617 (2021) PubMed Link PDF
  8. Goike J, Hsieh C-L, Horton A, Gardner AC, Bartzoka F, Wang N, Javanmardi K, Herbert A, Abbassi S, Renberg R, Johanson MJ, Cardona JA, Segall-Shapiro T, Zhou L, Nissly RH, Gontu A, Byrom M, Maranhao AC, Battenhouse AM, Gejji V, Soto-Sierra L, Foster ER, Woodard SL, Nikolov ZL, Lavinder J, Voss WN, Annapareddy A, Ippolito GC, Ellington AD, Marcotte EM, Finkelstein IJ, Hughes RA, Musser JM, Kuchipudi SJ, Kapur V, Georgiou G, Dye JM, Boutz DR, McLellan JS, Gollihar JD, Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality, bioRxiv, Posted April 9: (2021) PubMed Link
  9. McWhite CD, Papoulas O, Drew K, Dang V, Leggere JC, Sae-Lee W, Marcotte EM, Co-fractionation/mass spectrometry to identify protein complexes, STAR Protocols, 2(1):100370 (2021) PubMed Link PDF
  10. Roberson E, Battenhouse A, Garge RK, Tran NK, Marcotte EM, Wallingford JB, Spatiotemporal transcriptional dynamics of the cycling mouse oviduct, Developmental Biology, 476 (2021):240–248 (2021) PubMed Link PDF bioRxiv preprint (deposited Jan 15, 2021)
    DevBioCover 2021 small.jpg
  11. McCafferty CL, Taylor DW, Marcotte EM, Improving integrative 3D modeling into low- to medium- resolution EM structures with evolutionary couplings, Protein Science, 30:1006–1021 (2021) PubMed Link PDF bioRxiv preprint (deposited January 14, 2021)


  1. Floyd BM, Drew K, Marcotte EM, Systematic Identification of Protein Phosphorylation-Mediated Interactions, J Proteome Research, 20(2):1359-1370 (2021) PubMed Link PDF bioRxiv preprint (deposited Sept 19, 2020)
  2. Drew K, Wallingford JB, Marcotte EM, hu.MAP 2.0: Integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies, Molecular Systems Biology, 17:e10016 (2021) PubMed Link PDF bioRxiv preprint (deposited Sept 16, 2020)
  3. Devitt C, Lee C, Cox R, Papoulas O, Alvarado J, Marcotte EM, Wallingford JB, Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation, J Cell Science, 134(14):jcs254011 (2021) PubMed Link PDF bioRxiv preprint (deposited September 3, 2020) Research Highlight
  4. Boulgakov AA, Moor SR, Jo HH, Metola P, Joyce LA, Marcotte EM, Welch CJ, Anslyn EV, Next-Generation TLC: A Quantitative Platform for Parallel Spotting and Imaging, J Org Chem, 85(15):9447–9453 (2020) PubMed Link PDF
  5. Garge RK, Laurent JM, Kachroo AH, Marcotte EM, Systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genes, Genetics, 215(4):1153-1169 (2020) PubMed PDF bioRxiv preprint (deposited December 17, 2019)
  6. Laurent J, Garge RK, Teufel AI, Wilke CO, Kachroo AH, Marcotte EM, Humanization of yeast genes with multiple human orthologs reveals principles of functional divergence between paralogs, PLoS Biology, 18(5):e3000627 (2020) PubMed Link PDF bioRxiv preprint (deposited June 13, 2019)
  7. Lee C, Cox RM, Papoulas O, Horani A, Drew K, Devitt CC, Brody SL, Marcotte EM, Wallingford JB, Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins, eLife, 9:e58662 (2020) PubMed Link PDF bioRxiv preprint (deposited April 21, 2020)
  8. McWhite CD, Papoulas O, Drew K, Cox RM, June V, Dong OX, Kwon T, Wan C, Salmi ML, Roux, SJ Jr., Browning KS, Chen ZJ, Ronald PC, Marcotte EM, A pan-plant protein complex map reveals deep conservation and novel assemblies, Cell, 181(2):460-474.e14 (2020) PubMed Link PDF bioRxiv preprint (deposited October 24, 2019) plant.MAP supporting web site Protein elution profile data repository on Zenodo
  9. McCafferty C, Verbeke EJ, Marcotte EM, Taylor DW, Structural Biology in the Multi-Omics Era, Journal of Chemical Information and Modeling, 60(5):2424-2429 (2020) PubMed Link PDF
  10. Blank HM, Papoulas O, Maitra N, Garge RK, Kennedy BK, Schilling B, Marcotte EM, Polymenis M, Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveals coordinate control of lipid metabolism, Molecular Biology of the Cell, 31:1061-1084 (2020) PubMed Link PDF bioRxiv preprint (deposited Dec 18, 2019)
  11. Drew K, Lee C, Cox RM, Dang V, Devitt CC, Papoulas O, Huizar RL, Marcotte EM, Wallingford JB, A systematic, label-free method for identifying RNA-associated proteins in vivo provides insights into vertebrate ciliary beating, Developmental Biology, 467(1-2):108-117 (2020) PubMed Link PDF bioRxiv preprint (deposited Feb 27, 2020)
  12. Liebeskind BJ, Young RL, Halling DB, Aldrich RW, Marcotte EM, Mapping functional protein neighborhoods in the mouse brain, bioRxiv, Posted January 27: (2020) PubMed Link
  13. Howard CJ, Floyd BM, Bardo AM, Swaminathan J, Marcotte EM, Anslyn EV, Solid-phase peptide capture and release for bulk and single-molecule proteomics, ACS Chemical Biology, 15(6):1401-1407 (2020) PubMed Link PDF Supplement bioRxiv preprint (deposited January 14, 2020)
  14. Verbeke E, Zhou Y, Horton AP, Mallam AL, Taylor DW, Marcotte EM, Separating distinct structures of multiple macromolecular assemblies from cryo-EM projections, Journal of Structural Biology, 209(1):107416 (2020) PubMed Link PDF SLICEM code on Github bioRxiv preprint (deposited Apr 20, 2019)
  15. Bachman JL, Pavlich CI, Boley AJ, Marcotte EM, Anslyn EV, Synthesis of Carboxy ATTO 647N Using Redox Cycling for Xanthone Access, Org Lett, 22(2):381-385 (2020) PubMed Link PDF


  1. McCafferty CL, Marcotte EM, Taylor DW, Simplified geometric representations of protein structures identify complementary interaction interfaces, Proteins: Structure, Function, and Bioinformatics, 89(3):348-360 (2021) PubMed Link PDF bioRxiv preprint (deposited Dec 23, 2019)
  2. Kim JJ, Lee SY, Gong F, Battenhouse AM, Boutz DR, Bashyal A, Refvik ST, Chiang CM, Xhemalce B, Paull TT, Brodbelt JS, Marcotte EM, Miller KM, Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity, Genes and Development, 33(23-24):1751-1774 (2019) PubMed Link PDF
  3. Mallam AL, Sae-Lee W, Schaub JM, Tu F, Battenhouse A, Jang YJ, Kim J, Finkelstein IJ, Marcotte EM, Drew K, Systematic discovery of endogenous human ribonucleoprotein complexes, Cell Reports, 29(5):P1351-1368.e5 (2019) PubMed Link PDF bioRxiv preprint (deposited Nov 27, 2018)
  4. Liebeskind B, Aldrich RW, Marcotte EM, Ancestral Reconstruction of Protein Interaction Networks, PLoS Computational Biology, 15(10):e1007396 (2019) PubMed Link PDF bioRxiv preprint (deposited September 9, 2018)
  5. Glover N, Dessimoz C, Ebersberger I, Forslund SK, Gabaldón T, Huerta-Cepas J, Martin MJ, Muffato M, Patricio M, Pereira C, Sousa da Silva A, Wang Y, Sonnhammer E, Thomas PD; Quest for Orthologs Consortium, Advances and Applications in the Quest for Orthologs., Mol Biol Evol, 36(10):2157-2164 (2019) PubMed Link PDF
  6. Boulgakov AA, Ellington AD, Marcotte EM, Bringing Microscopy-By-Sequencing into View, Trends in Biotechnology, 38(2):154-162 (available online 2019, published 2020) PubMed Link PDF


  1. Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R, Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus, Nature, 553:337–341 (2018) PubMed Link PDF
  2. Huizar RL, Lee C, Boulgakov AA, Horani A, Tu F, Marcotte EM, Brody SL, Wallingford JB, A liquid-like organelle at the root of motile ciliopathy, eLife, 7:e38497 (2018) PubMed Link PDF bioRxiv preprint (deposited Nov 3, 2017)
  3. Boulgakov AA, Xiong E, Bhadra S, Ellington AD, Marcotte EM, From Space to Sequence and Back Again: Iterative DNA Proximity Ligation and its Applications to DNA-Based Imaging, bioRxiv, posted November 14: (2018) PubMed Link
  4. Hwang S, Kim CY, Yang S, Kim E, Hart T, Marcotte EM, Lee I, HumanNet v2: human gene networks for disease research, Nucleic Acids Res, 47 (D1):D573–D580 (2018,2019) PubMed Link PDF
  5. Swaminathan J, Boulgakov AA, Hernandez ET, Bardo AM, Bachman JL, Marotta J, Johnson AM, Anslyn EV, Marcotte EM, Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures, Nature Biotechnology, 36:1076–1082 (2018) PubMed Link PDF Free access authors' view-only version at NBT Supplement Supplementary Tables github with code Data repository (Zenodo) News & Views Commentary in
  6. Teufel AI, Johnson MM, Laurent JM, Kachroo AH, Marcotte EM, Wilke CO, The many nuanced evolutionary consequences of duplicated genes, Mol Bio Evol, 36(2):304-314 (2018) PubMed Link PDF bioRxiv preprint (deposited July 10, 2018)
  7. Sun X, Boulgakov AA, Smith L, Metola P, Marcotte EM, Anslyn EV, Photography Coupled with Self-Propagating Chemical Cascades. The Differentiation and Quantitation of G and V Nerve Agent Mimics via Chromaticity, ACS Central Science, 4(7):854-861 (2018) PubMed Link PDF
  8. Verbeke EJ, Mallam AL, Drew K, Marcotte EM, Taylor DW, Classification of single particles from human cell extract reveals distinct structures, Cell Reports, (24)1:259–268.e3 (2018) PubMed Link PDF bioRxiv preprint (deposited January 14 , 2018)
  9. Akhmetov A, Laurent JM, Gollihar J, Gardner EC, Garge RK, Ellington AD, Kachroo AH, Marcotte EM, Single-step precision genome editing in yeast using CRISPR-Cas9, Bio-protocol, 8(6):e2765 (2018) PubMed Link PDF
  10. Tu F, Sedzinski J, Ma Y, Marcotte EM, Wallingford JB, Protein localization screening in vivo reveals novel regulators of multiciliated cell development and function, J Cell Sci, 131 (3):jcs206565 (2018) PubMed Link PDF


  1. Hernandez ET, Swaminathan J, Marcotte EM , Anslyn EV, Solution-phase and solid-phase sequential, selective modification of side chains in KDYWEC and KDYWE as models for usage in single-molecule protein sequencing, New Journal of Chemistry, 41:462-469 (2017) PubMed Link PDF
  2. Drew K, Müller CL, Bonneau R, Marcotte EM, Identifying direct contacts between protein complex subunits from their conditional dependence in proteomics datasets, PLoS Computational Biology, 13(10):e1005625 (2017) PubMed Link PDF
  3. Kuboniwa M, Houser JR, Hendrickson EL, Wang Q, Alghamdi SA, Sakanaka A, Miller DP, Hutcherson JA, Wang T, Beck DAC, Whiteley M, Amano A, Wang H, Marcotte EM, Hackett M, Lamont RJ, Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection, Nature Microbiology, 2:1493–1499 (2017) PubMed Link PDF
  4. Kachroo AH, Laurent JM, Akhmetov A, Szilagyi-Jones M, McWhite CD, Zhao A, Marcotte EM, Systematic bacterialization of yeast genes identifies a near-universally swappable pathway, eLife, 6:e25093 (2017) PubMed Link PDF
  5. Akhmetov A, Ellington A, Marcotte E, A highly parallel strategy for storage of digital information in living cells, BMC Biotechnology, 18:64 (2018) PubMed Link PDF bioRxiv preprint (deposited December 26, 2016) Open access pdf version of the article
  6. Mallam A, Marcotte EM, Systems-wide studies uncover Commander, a multiprotein complex essential to human development, Cell Systems, 4:483-494 (2017) PubMed Link PDF
  7. Drew, K., Lee, C., Huizar, R. L., Tu, F., Borgeson, B., McWhite, C. D., Ma, Y., Wallingford, J. B., Marcotte, E. M., Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes, Molecular Systems Biology, 13:932 (2017) PubMed Link PDF bioRxiv preprint (deposited December 7, 2016)
  8. Shim JE, Bang C, Yang S, Lee T, Hwang S, Kim CY, Singh-Blom UM, Marcotte EM, Lee I, GWAB: a web server for the network-based boosting of human genome-wide association data, Nucleic Acids Research, 89(6):3747–3753 (2017) PubMed Link PDF
  9. Caglar MU, Houser JR, Barnhart CS, Boutz DR, Carroll SM, Dasgupta A, Lenoir WF, Smith BL, Sridhara V, Sydykova DK, Vander Wood D, Marx CJ, Marcotte EM, Barrick JE, Wilke CO, The E. coli molecular phenotype under different growth conditions, Scientific Reports, 7:45303 (2017) PubMed Link PDF
  10. Brown CW, Sridhara V, Boutz DR, Person MD, Marcotte EM, Barrick JE, Wilke CO, Large-scale analysis of post-translational modifications in E. coli under glucose-limiting conditions, BMC Genomics, 18(1):301 (2017) PubMed Link PDF
  11. AP Horton, SA Robotham, JR Cannon, DD Holden, EM Marcotte, Brodbelt JS, Comprehensive de novo peptide sequencing from MS/MS pairs generated through complementary collision induced dissociation and 351 nm ultraviolet photodissociation, Analytical Chemistry, 89(6):3747–3753 (2017) PubMed Link PDF
  12. Lee T, Hwang S, Kim CY, Shim H, Kim H, Ronald PC, Marcotte EM, Lee I, WheatNet: A genome-scale functional network for hexaploid bread wheat, Triticum aestivum, Molecular Plant, S1674-2052(17):30108-9 (2017) PubMed Link PDF bioRxiv preprint (deposited February 6, 2017)
  13. Hilterbrand AT, Boutz DR, Marcotte EM, Upton JW, Murine Cytomegalovirus Deubiquitinase Regulates Viral Chemokine Levels To Control Inflammation and Pathogenesis, mBio, 8:e01864-16 (2017) PubMed Link PDF


  1. Young JH, Peyton M, Kim HS, McMillan E, Minna JD, White MA, Marcotte EM, Computational Discovery of Pathway-Level Genetic Vulnerabilities in Non-Small-Cell Lung Cancer, Bioinformatics, 32(9):1373-9 (2016) PubMed Link PDF Supporting code
  2. Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, Druz A, Zhang B, Zhang Y, Wang L, Kong WP, Park D, Popova LI, Dekker CL, Davis MM, Carter CE, Ross TM, Ellington AD, Wilson PC, Marcotte EM, Mascola JR, Ippolito GC, Krammer F, Quake SR, Kwong PD, Georgiou G, Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination, Nature Medicine, 22(12):1456-1464 (2016) PubMed Link PDF
  3. Session AM*, Uno Y*, Kwon T*, et al., Genome evolution in the allotetraploid frog Xenopus laevis, Nature, 538:336–343 (2016) PubMed Link PDF News&Views and pdf; Supplementary Information
  4. Wu GC, Cheung NV, Georgiou G, Marcotte EM, Ippolito GC, Temporal Stability and Molecular Persistence of the Bone Marrow Plasma Cell Antibody Repertoire, Nature Communications, 7:13838 (2016) PubMed Link PDF bioRxiv preprint (deposited August 2, 2016)
  5. Toriyama M, Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelly MR, Kim S, Park TJ, Braun D, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco B, Al-Lami HA, Yeung Y, Choi YJ; University of Washington Center for Mendelian Genomics, Duffourd Y, Faivre L, Rivière JB, Chen J, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB, The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery, Nature Genetics, 48(6):648-56 (2016) PubMed Link PDF
  6. Young JH, Marcotte EM, Predicting Drug Synergy and Antagonism from Genetic Interaction Neighborhoods, bioRxiv, :deposited April 27 (2016) PubMed Link
  7. Young JH, Marcotte EM, Predictability of Genetic Interactions from Functional Gene Modules, G3, 7:617-624 (2016) PubMed Link PDF bioRxiv preprint (deposited April 25, 2016)
  8. Teperek M, Simeone A, Gaggioli V, Miyamoto K, Allen G, Erkek S, Peters A, Kwon T, Marcotte E, Zegerman P, Bradshaw C, Gurdon J, Jullien J, Sperm is epigenetically programmed to regulate gene transcription in embryos, Genome Research, 26:1034-1046 (2016) PubMed Link PDF
  9. Liebeskind BJ, McWhite CD, Marcotte EM, Towards Consensus Gene Ages, Genome Biology and Evolution, 8(6):1812-23 (2016) PubMed Link PDF bioRxiv preprint (deposited March 1) Supporting code and datasets
  10. Robotham SA, Horton AP, Cannon JR, Cotham VC, Marcotte EM, Brodbelt JS, UVnovo: A de Novo Sequencing Algorithm Using Single Series of Fragment Ions via Chromophore Tagging and 351 nm Ultraviolet Photodissociation Mass Spectrometry, Analytical Chemistry, 88(7):3990-7 (2016) PubMed Link PDF Supporting code


  1. Woods JO, Tien M, Marcotte EM, Interrogating conserved elements of diseases using Boolean combinations of orthologous phenotypes, bioRxiv, posted April 13: (2015) PubMed Link
  2. Phanse S, Wan C, Borgeson B, Tu F, Drew K, Clark G, Xiong X, Kagan O, Kwan J, Bezginov A, Chessman K, Pal S, Cromar G, Papoulas O, Ni Z, Boutz DR, Stoilova S, Havugimana PC, Guo X, Malty RH, Sarov M, Greenblatt J, Babu M, Derry WB, R Tillier E, Wallingford JB, Parkinson J, Marcotte EM, Emili A, Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes, Data in Brief, 6:715-21 (2015) PubMed Link PDF
  3. Kim E, Hwang S, Kim H, Shim H, Kang B, Yang S, Shim JH, Shin SY, Marcotte EM, Lee I, MouseNet v2: A database of gene networks for studying the laboratory mouse and eight other model vertebrates, Nucl. Acid. Res., 44(D1):D848-54 (2015) PubMed Link PDF
  4. Murray J, Kwon T, Marcotte EM, Whiteley M, Intrinsic antimicrobial resistance determinants in the 'superbug' P. aeruginosa, mBio, 6(6):e01603-15 (2015) PubMed Link PDF
  5. Poldrack RA, Laumann T, Koyejo O, Gregory B, Hover A, Chen M-Y, Luci J, Huk A, Joo S-J, Boyd R, Hunicke-Smith S, Simpson ZB, Caven T, Sochat V, Shine JM, Gordon E, Snyder AZ, Adeyemo B, Petersen SE, Glahn D, Mckay DR, Blangero J, Frick L, Marcotte EM, Mumford JA, Long-term neural and physiological phenotyping of a single human, Nature Communications, 6:Article #8885 (2015) PubMed Link PDF
  6. Hwang S, Eiru K, Lee I, Marcotte EM, Systematic comparison of variant calling pipelines using gold standard personal exome variants, Scientific Reports, 5:17875 (2015) PubMed Link PDF Example variant calling parameters Gold standard vcf and exome capture region bed files
  7. Laurent JM, Young JH, Kachroo AH, Marcotte EM, Efforts to make and apply humanized yeast, Briefings in Functional Genomics, 15(2):155-63 (2015) PubMed Link PDF
  8. Wan C, Borgeson B, Phanse S, Tu F, Drew K, Clark G, Xiong X, Kagan O, Kwan J, Bezginov A, Chessman K, Pal S, Cromar G, Papoulas O, Ni Z, Boutz DR, Stoilova S, Havugimana PC, Guo X, Malty RH, Sarov M, Greenblatt J, Babu M, Derry WB, R Tillier E, Wallingford JB, Parkinson J, Marcotte EM, Emili A, Panorama of ancient metazoan macromolecular complexes, Nature, 525:339–344 (2015) PubMed Link PDF Supplementary data is available here. Supporting web site
  9. McWhite CD, Liebeskind BJ, Marcotte EM, Applications of comparative evolution to human disease genetics, Current Opinion in Genetics & Development, 35:16–24 (2015) PubMed Link PDF COGD supplies a direct link around their paywall for free access to the paper
  10. Houser JR, Barnhart C, Boutz DR, Carroll SM, Dasgupta A, Michener JK, Needham BD, Papoulas O, Sridhara V, Sydykova DK, Marx CJ, Trent MS, Barrick JE, Marcotte EM, Wilke CO, Controlled Measurement and Comparative Analysis of Cellular Components in E. coli Reveals Broad Regulatory Changes in Response to Glucose Starvation, PLoS Computational Biology, 11(8):e1004400 (2015) PubMed Link PDF
  11. Kachroo AH, Laurent JM, Yellman CM, Meyer AG, Wilke CO, Marcotte EM, Systematic humanization of yeast genes reveals conserved functions and genetic modularity, Science, 348(6237):921-925 (2015) PubMed Link PDF Supplement Supplementary Tables and Files Science magazine supplies a direct link around their paywall for free access to the manuscript and pdf reprint. Code and data for protein interaction evolution simulations are here
  12. Lee I, Kim E, Marcotte EM, Modes of Interaction between Individuals Dominate the Topologies of Real World Networks, PLoS One, 10(3):e0121248 (2015) PubMed Link PDF
  13. Sardana R, Liu X, Granneman S, Zhu J, Gill M, Papoulas O, Marcotte EM, Tollervey D, Correll CC, Johnson AW, The DEAH-box helicase Dhr1 dissociates U3 from the pre-rRNA to promote folding the central pseudoknot, PLoS Biology, 13(2):e1002083 (2015) PubMed Link PDF
  14. Brown KA, Yang X, Schipper D, Hall JW, DePue LJ, Gnanam AJ, Arambula JF, Jones JN, Swaminathan J, Dieye Y, Vadivelu J, Chandler DJ, Marcotte EM, Sessler JL, Ehrlich LIR, Jones RA, A self-assembling lanthanide molecular nanoparticle for optical imaging, Dalton Transactions, 44(6):2667-75 (2015) PubMed Link PDF


  1. Swaminathan J, Boulgakov AA, Marcotte EM, A theoretical justification for single molecule peptide sequencing, PLoS Computational Biology, 11(2):e1004080 (2014 bioRxiv, 2015 PLoS CB) PubMed Link PDF bioRxiv preprint
  2. Jones RA, Gnanam AJ, Arambula JF, Jones JN, Swaminathan J, Yang X, Schipper D, Hall JW, DePue LJ, Dieye Y, Vadivelu J, Chandler DJ, Marcotte EM, Sessler JL, Ehrlich LIR, Brown KA, Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications, Faraday Discussions, 175:241-55 (2014) PubMed Link PDF
  3. Kwon T, Chung M-I, Gupta R, Baker JC, Wallingford JB, Marcotte EM, Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement, Genomics Data, 2:192-194 (2014) PubMed Link PDF
  4. Hwang S, Kim E, Yang S, Marcotte EM, Lee I, MORPHIN: a web tool for human disease research by projecting model organism biology onto a human integrated gene network, Nucleic Acids Research, 42(Web Server issue):W147-53 (2014) PubMed Link PDF
  5. Kwon T, Huse HK, Vogel C, Whiteley M, Marcotte EM, Protein-to-mRNA ratios are conserved between Pseudomonas aeruginosa strains, Journal of Proteome Research, 13(5):2370-80 (2014) PubMed Link PDF
  6. Boutz DR, Horton AP, Wine Y, Lavinder JJ, Georgiou G, Marcotte EM, Proteomic identification of monoclonal antibodies from serum, Analytical Chemistry, 86(10):4758-66 (2014) PubMed Link PDF
  7. O’Connell JD, Tsechansky M, West-Driga M, Marcotte EM, Formation of intracellular glutamine synthetase bodies depends strongly upon cellular age and glucose availability, PeerJ PrePrints, 2:e270v1 (2014) PubMed Link PDF
  8. O’Connell JD, Tsechansky M, Royall A, Boutz DR, Ellington AD, Marcotte EM, A proteomic survey of widespread protein aggregation in yeast, Molecular BioSystems, 10:851-861 (2014) PubMed Link PDF Supplement Supporting Datasets
  9. Hammerling MJ, Ellefson JW, Boutz DR, Marcotte EM, Ellington AD, Barrick JE, Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness, Nature Chemical Biology, 10(3):178-80 (2014) PubMed Link PDF Supplement Supplemental Data 1 Supplemental Data 2
  10. Qian Y, Kachroo A, Yellman CM, Marcotte EM, Johnson KA, Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progression, Journal of Biological Chemistry, 289:5970-5985 (2014) PubMed Link PDF
  11. Lavinder JJ, Wine Y, Giesecke C, Ippolito GC, Horton AP, Lungu OI, Hoi KH, Dekosky BJ, Murrin EM, Wirth MM, Ellington AD, Dörner T, Marcotte EM, Boutz DR, Georgiou G, Identification and characterization of the constituent human serum antibodies elicited by vaccination, Proc Natl Acad Sci USA, 111(6):2259-64 (2014) PubMed Link PDF
  12. Zhao A, Tsechansky M, Ellington AD, Marcotte EM, Revisiting and revising the purinosome, Molecular BioSystems, 10(3):369-74 (2014) PubMed Link PDF
  13. Chung MI*, Kwon T*, Tu F, Brooks ER, Gupta R, Meyer M, Baker JC, Marcotte EM, Wallingford JB, Coordinated genomic control of ciliogenesis and cell movement by Rfx2, eLife, 3:e01439 (2014) PubMed Link PDF Supplement


  1. Gerster S, Kwon T, Ludwig C, Matondo M, Vogel C, Marcotte E, Aebersold R, Bühlmann P, Statistical approach to protein quantification, Mol Cell Proteomics, 13(2):666-77 (2014) PubMed Link PDF
  2. Huse HK, Kwon T, Zlosnik JEA, Speert DP, Marcotte EM, Whiteley M, Pseudomonas aeruginosa enhances production of a non-alginate exopolysaccharide during long-term colonization of the cystic fibrosis lung, PLoS One, 8(12):e82621 (2013) PubMed Link PDF
  3. Li Z*, Park Y*, Marcotte EM, A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF, PLoS Biology, 11(8):e1001624 (2013) PubMed Link PDF Commentary
  4. Woods JO, Singh-Blom UM, Laurent JM, McGary KL, Marcotte EM, Prediction of gene-phenotype associations in humans, mice, and plants using phenologs, BMC Bioinformatics, 14:203 (2013) PubMed Link PDF
  5. Singh-Blom UM, Natarajan N, Tewari A, Woods JO, Dhillon IS, Marcotte EM, Prediction and validation of gene-disease associations using methods inspired by social network analyses, PLoS One, 8(5):e58977 (2013) PubMed Link PDF Supplement
  6. Zhou L, Zhang AB, Wang R, Marcotte EM, Vogel C, The proteomic response to mutants of the Escherichia coli RNA degradosome, Molecular BioSystems, 9:750-757 (2013) PubMed Link PDF
  7. Wine Y, Boutz DR, Lavinder JJ, Miklos AE, Hughes RA, Hoi KH, Jung ST, Horton AP, Murrin EM, Ellington AD, Marcotte EM, Georgiou G, Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response, Proc Natl Acad Sci USA, 110(8):2993–2998 (2013) PubMed Link PDF
  8. Zhao A, Tsechansky M, Swaminathan J, Cook L, Ellington AD, Marcotte EM, Transiently transfected purine biosynthetic enzymes form stress bodies, PLoS One, 8(2):e56203 (2013) PubMed Link PDF


  1. Wang PI, Hwang S, Kincaid RP, Sullivan CS, Lee I, Marcotte EM, RIDDLE: Reflective diffusion and local extension reveal functional associations for unannotated gene sets via proximity in a gene network, Genome Biology, 13(12):R125 (2012) PubMed Link PDF
  2. Wessel AK, Liew J, Kwon T, Marcotte EM, Whiteley M, The role of Pseudomonas aeruginosa peptidoglycan-associated outer membrane proteins in vesicle formation, J Bacteriol, 195(2):213-9 (2012) PubMed Link PDF Supplemental data
  3. Park Y, Marcotte EM, Flaws in evaluation schemes for pair-input computational predictions, Nature Methods, 9(12):1134–1136 (2012) PubMed Link PDF Supplement
  4. Havugimana PC, Hart GT, Nepusz T, Yang H, Turinsky AL, Li Z, Wang P, Boutz DR, Fong V, Babu M, Craig SA, Hu P, Phanse S, Wan C, Vlasblom J, Dar V, Bezginov A, Wu GC, Wodak SJ, Tillier ERM, Paccanaro A, Marcotte EM, Emili A, Census of human soluble protein complexes, Cell, 150:1068-1081 (2012) PubMed Link PDF Supporting web site Research highlight
  5. Uribe RA, Kwon T, Marcotte EM, Gross JM, Id2a functions to limit Notch pathway activity and thereby influence retinoblast proliferation to differentiation of retinoblasts during zebrafish retinogenesis, Developmental Biology, 371:280–292 (2012) PubMed Link PDF
  6. Cha HJ, Byrom M, Mead PE, Ellington AD, Wallingford JB, Marcotte EM, Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent, PLoS Biology, 10(8):e1001379 (2012) PubMed Link PDF Supplemental Material Synopsis NY Times NIGMS video
  7. O'Connell JD, Zhao A, Ellington AD, Marcotte EM, Dynamic reorganization of metabolic enzymes into intracellular bodies, Annual Review of Cell and Developmental Biology, 28:89-111 (2012) PubMed Link PDF
  8. Vogel C, Marcotte EM, Insights into the regulation of protein abundance from proteomic and transcriptomic analyses, Nature Reviews Genetics, 13:227-232 (2012) PubMed Link PDF
  9. Orr SJ, Boutz DR, Wang R, Chronis C, Lea NC, Thayaparan T, Hamilton E, Milewicz H, Blanc E, Mufti GJ, Marcotte EM, Thomas NSB, Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry, Molecular Systems Biology, 8:573 (2012) PubMed Link PDF Supplement Reviewer comments
  10. Chung M-I, Peyrot S, LeBoeuf S, Park TJ, McGary KL, Marcotte EM, Wallingford JB, RFX2 is broadly required for ciliogenesis during vertebrate development, Developmental Biology, 363(1):155-165 (2012) PubMed Link PDF Supplement
  11. Vogel C, Marcotte EM, Label-free quantitation using weighted spectral counting, Methods in Molecular Biology: Quantitative Methods in Proteomics, Marcus, K., ed., Humana Press, vol. 893(3):321-341 (2012) PubMed Link PDF


  1. Lee I, Seo Y-S, Coltrane D, Hwang S, Oha T, Marcotte EM, Ronald PC, Genetic dissection of the biotic stress response using a genome-scale gene network for rice, Proc Natl Acad Sci USA, 108(45):18548-18553 (2011) PubMed Link PDF Supplement
  2. Natarajan N, Blom UM, Tewari A, Woods JO, Dhillon IS, Marcotte EM, Predicting gene-disease associations using multiple species data, UTCS Technical Report, TR-11-37: (2011) PubMed Link PDF
  3. Vogel C, Silva GM, Marcotte EM, Global protein expression regulation under oxidative stress, Molecular and Cellular Proteomics, 10(12):M111.009217 (2011) PubMed Link PDF Supplement
  4. Park Y, Marcotte EM, Revisiting the negative example sampling problem for predicting protein-protein interactions, Bioinformatics, 27(21):3024-3028 (2011) PubMed Link PDF Supplemental Data
  5. Hwang S, Rhee SY, Marcotte EM, Lee I, Systematic prediction of gene function using a probabilistic functional gene network for Arabidopsis thaliana, Nature Protocols, 6:1429–1442 (2011) PubMed Link PDF
  6. Lee I, Blom M, Wang PI, Shim JE, Marcotte EM, Prioritizing candidate disease genes by network-based boosting of genome-wide association data, Genome Research, 21(7):1109-21 (2011) PubMed Link PDF Supplement HumanNet web site
  7. Kwon T, Choi H, Vogel C, Nesvizhskii AI, Marcotte EM, MSblender: a probabilistic approach for integrating peptide identifications from multiple database search engines, Journal of Proteome Research, 10(7):2949-58 (2011) PubMed Link PDF Supplemental Figures 1 2 3 4 Supporting web site
  8. Boutz DR, Collins P, Suresh U, Lu M, Ramírez CM, Fernández-Hernando C, Huang Y, de Sousa Abreu R, Le SY, Shapiro BA, Liu AM, Luk JM, Aldred SF, Trinklein N, Marcotte EM, Penalva LO, A two-tiered approach identifies a network of cancer and liver diseases related genes regulated by miR-122, Journal of Biological Chemistry, 286(20):18066-78 (2011) PubMed Link PDF
  9. Niu W, Hart GT, Marcotte EM, High-throughput immunofluorescence microscopy using yeast spheroplast microarrays, Methods in Molecular Biology: Cell-Based Microarrays, Palmer, E., ed., Humana Press, vol. 706:83-95 (2011) PubMed PDF
  10. Smith KR, Kieserman EK, Wang PI, Basten SG, Giles RH, Marcotte EM, Wallingford JB, A role for central spindle proteins in cilia structure and function, Cytoskeleton, 68(2):112-24 (2011) PubMed Link PDF


  1. Huse HK, Kwon T, Zlosnik JEA, Speert DP, Marcotte EM, Whiteley M, Parallel evolution in Pseudomonas aeruginosa over 39,000 generations in vivo, mBIO, 1(4):e00199-10 (2010) PubMed Link PDF ScienceNews Supplement
  2. Huang N, Lee I, Marcotte EM, Hurles M, Characterising and predicting haploinsufficiency in the human genome, PLoS Genetics, 6(10):e1001154 (2010) PubMed Link PDF
  3. Laurent J, Vogel C, Kwon T, Craig SA, Boutz DR, Huse HK, Nozue K, Walia H, Whiteley M, Ronald PC, Marcotte EM, Protein abundances are more conserved than mRNA abundances across diverse taxa, Proteomics, 10:4209–4212 (2010) PubMed Link PDF Supplement
  4. Wang PI, Marcotte EM, It's the machine that matters: predicting gene function and phenotype from protein networks, Journal of Proteomics, 73(11):2277-89 (2010) PubMed Link PDF
  5. Vogel C, de Sousa Abreu R, Ko D, Le S-Y, Shapiro BA, Burns SC, Sandhu D, Boutz DR, Marcotte EM, Penalva LO, Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line, Molecular Systems Biology, 6:article 400 (2010) PubMed Link PDF Supplement Supplemental Data (Excel format) Fig 2 source data Fig 3A source data Fig 3B source data News and Views
  6. Lo K-Y, Li Z, Bussiere C, Bresson S, Marcotte EM, Johnson AW, Defining the pathway of cytoplasmic maturation of the 60S ribosomal subunit, Molecular Cell, 39(2):196-208 (2010) PubMed Link PDF Supplement
  7. Lee I, Lehner B, Vavouri T, Shin J, Fraser AG, Marcotte EM, Predicting genetic modifier loci using functional gene networks, Genome Research, 20:1143-1153 (2010) PubMed Link PDF Supplement Nature Reviews Genetics
  8. McGary KL, Park TJ, Woods JO, Cha HJ, Wallingford JB, Marcotte EM, Systematic discovery of nonobvious human disease models through orthologous phenotypes, Proc Natl Acad Sci U S A, 107(14):6544-9 (2010) PubMed Link PDF Supplement Nature News The Scientist(blog) NY Times Genome Biology
  9. Orr SJ, Gaymes T, Ladon D, Chronis C, Czepulkowski B, Wang R, Mufti GJ, Marcotte EM, Thomas NSB, Reducing MCM levels in human primary T cells during the G0->G1 transition causes genomic instability during the first cell cycle, Oncogene, 29(26):3803-14 (2010) PubMed Link PDF
  10. Lee I, Ambaru B, Thakkar P, Marcotte EM, Rhee SY, Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana, Nature Biotechnology, 28(2):149-156 (2010) PubMed Link PDF Supplement Honorable Mention in the 2010 Science Visualization Challenge New York Times slideshow


  1. Li Z, Lee I, Moradi E, Hung NJ, White J, Johnson AW, Marcotte EM, Rational extension of the ribosome biogenesis pathway using network-guided genetics, PLoS Biology, 7(10):e1000213 (2009) PubMed Link PDF Supplemental Figures and Tables
  2. Hart GT, Zhao A, Garg A, Bolusani S, Marcotte EM, Human cell chips: adapting DNA microarray spotting technology to cell-based imaging assays, PLoS One, 4(10):e7088 (2009) PubMed Link PDF Table S1
  3. Lo KY, Li Z, Wang F, Marcotte EM, Johnson AF, Ribosome stalk assembly requires the dual specificity phosphatase Yvh1 for the exchange of Mrt4 with P0, J. Cell Biology, 186(6):849-62 (2009) PubMed Link PDF Supplemental material
  4. Vogel C, Marcotte EM, Absolute abundance for the masses, Nature Biotechnology, 27(9):825-6 (2009) PubMed Link PDF
  5. de Sousa Abreu R, Penalva LO, Marcotte EM, Vogel C, Global signatures of protein and mRNA expression levels, Molecular BioSystems, 5:1512–1526 (2009) PubMed Link PDF
  6. Gray RS, Abitua PB, Wlodarczyk BJ, Blanchard O, Lee I, Weiss G, Marcotte EM, Wallingford JB, Finnell RH, The planar cell polarity effector protein Fuzzy is essential for targeted membrane trafficking, ciliogenesis, and mouse embryonic development, Nature Cell Biology, 11(10):1225-32 (2009) PubMed Link PDF Journal cover--a beautiful electron micrograph by Phil Abitua Supplemental Figures
  7. Marcotte EM, Tsechansky M, Disorder, promiscuity, and toxic partnerships, Cell, 138(1):16-18 (2009) PubMed Link PDF
  8. Ramakrishnan SR, Vogel C, Kwon T, Penalva LO, Marcotte EM, Miranker DP, Mining gene functional networks to improve mass-spectrometry based protein identification, Bioinformatics, 25(22):2955-2961 (2009) PubMed Link PDF Supplemental Website
  9. Narayanaswamy R, Levy M, Tsechansky M, Stovall GM, O'Connell J, Mirrielees J, Ellington AD, Marcotte EM, Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation, Proc Natl Acad Sci U S A, 106(25):10147-52 (2009) PubMed Link PDF Supplemental methods Supplemental Dataset Table S1 Table S2 Table S3
  10. Tabor JJ, Salis H, Simpson ZB, Chevalier AA, Levskaya A, Marcotte EM, Voigt CA, Ellington AD, A synthetic genetic edge detection program, Cell, 137(7):1272-1281 (2009) PubMed Link PDF Supplemental methods
  11. Lee I, Marcotte EM, Effects of functional bias on supervised learning of a gene network model, Methods Mol Biol, 541:463-75 (2009) PubMed Link PDF
  12. Ramakrishnan SR, Vogel C, Prince JT, Wang R, Li Z, Penalva LO, Myers M, Marcotte EM, Miranker DP, Integrating shotgun proteomics and mRNA expression data to improve protein identification, Bioinformatics, 25(11):1397-403 (2009) PubMed Link PDF Supplement Supplemental website
  13. Narayanaswamy R, Moradi EK, Niu W, Hart GT, Davis M, McGary KL, Ellington AD, Marcotte EM., Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast., J Proteome Res., 8(1):6-19. (2009) PubMed Link PDF


  1. Hannay K, Marcotte EM, Vogel C, Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation, BMC Genomics, 9:609 (2008) PubMed Link PDF Supplemental Notes Supplemental Data
  2. Braisted JC, Kuntumalla S, Vogel C, Marcotte EM, Rodrigues AR, Wang R, Huang ST, Ferlanti ES, Saeed AI, Fleischmann RD, Peterson SN, Pieper R, The APEX Quantitative Proteomics Tool: generating protein quantitation estimates from LC-MS/MS proteomics results, BMC Bioinformatics, 9:529. (2008) PubMed Link PDF
  3. Kim WK, Marcotte EM, Age-dependent evolution of the yeast protein interaction network suggests a limited role of gene duplication and divergence, PLoS Comput Biol, 4(11):e1000232 (2008) PubMed Link PDF Supporting python code: Note that this code used an older version of the igraph library (0.4.2); the latest version that we've tested (0.5.2) gives somewhat fewer large clusters than our published clusters due to changes in the function "G.community_fastgreedy()", possibly resulting from modifications to the handling of ties in the community merging process. The previous igraph library (0.4.2) is linked here: python-igraph-0.4.2.tar.gz igraph-0.4.2.tar.gz
  4. Prince JT, Marcotte EM, mspire: mass spectrometry proteomics in Ruby, Bioinformatics, 24(23):2796-7 (2008) PubMed Link PDF
  5. Vogel C, Marcotte EM, Calculating absolute and relative protein abundance from mass spectrometry-based protein expression data, Nat Protoc, 3(9):1444-51. (2008) PubMed Link PDF Supplement
  6. Lee I, Marcotte EM, Integrating functional genomics data, Methods Mol Biol, 453:267-78. (2008) PubMed Link PDF
  7. Kim WK, Krumpelman C, Marcotte EM, Inferring mouse gene functions from genomic-scale data using a combined functional network/classification strategy, Genome Biol, 9 Suppl 1::S5 (2008) PubMed Link PDF Supplement
  8. Peña-Castillo L, Tasan M, Myers CL, Lee H, Joshi T, Zhang C, Guan Y, Leone M, Pagnani A, Kim WK, Krumpelman C, Tian W, Obozinski G, Qi Y, Mostafavi S, Lin GN, Berriz GF, Gibbons FD, Lanckriet G, Qiu J, Grant C, Barutcuoglu Z, Hill DP, Warde-Farley D, Grouios C, Ray D, Blake JA, Deng M, Jordan MI, Noble WS, Morris Q, Klein-Seetharaman J, Bar-Joseph Z, Chen T, Sun F, Troyanskaya OG, Marcotte EM, Xu D, Hughes TR, Roth FP, A critical assessment of Mus musculus gene function prediction using integrated genomic evidence, Genome Biol, 9 Suppl 1:S2 (2008) PubMed Link PDF MouseFunc predictions
  9. Niu W, Li Z, Zhan W, Iyer VR, Marcotte EM, Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae, PLoS Genet, 4(7):e1000120 (2008) PubMed Link PDF Supplemental File of All ORF FACS Defects
  10. Zhao J, Niu W, Yao J, Mohr S, Marcotte EM, Lambowitz AM, Group II intron protein localization and insertion sites are affected by polyphosphate, PLoS Biol, 6(6):e150 (2008) PubMed Link PDF
  11. Ramani AK, Li Z, Hart GT, Carlson MW, Boutz DR, Marcotte EM, A map of human protein interactions derived from co-expression of human mRNAs and their orthologs, Mol Syst Biol, 4:180 (2008) PubMed Link PDF
  12. White J, Li Z, Sardana R, Bujnicki JM, Marcotte EM, Johnson AW, Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits, Mol Cell Biol, 28(10):3151-61 (2008) PubMed Link PDF
  13. Wang R, Marcotte EM, The proteomic response of Mycobacterium smegmatis to anti-tuberculosis drugs suggests targeted pathways, J Proteome Res, 7(3):855-65 (2008) PubMed Link PDF
  14. Lee I, Lehner B, Crombie C, Wong W, Fraser AG, Marcotte EM, A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans, Nat Genet, 40(2):181-8 (2008) PubMed Link PDF Supplement Supplemental Web Site


  1. McGary KL, Lee I, Marcotte EM, Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes, Genome Biol, 8(12):R258. (2007) PubMed Link PDF Supplemental Web Site
  2. Lee I, Li Z, Marcotte EM, An improved, bias-reduced probabilistic functional gene network of baker's yeast, Saccharomyces cerevisiae, PLoS ONE, 2(10):e988 (2007) PubMed Link PDF Supplemental Web Site
  3. Marcotte EM, How do shotgun proteomics algorithms identify proteins?, Nat Biotechnol, 25(7):755-7 (2007) PubMed Link PDF
  4. Carlson MW, Iyer VR, Marcotte EM, Quantitative gene expression assessment identifies appropriate cell line models for individual cervical cancer pathways, BMC Genomics, 8:117. (2007) PubMed Link PDF
  5. Lu P, Vogel C, Wang R, Yao X, Marcotte EM, Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation, Nat Biotechnol, 25(1):117-24 (2007) PubMed Link PDF Supplement Supplemental Data (zipped folder) News & Views 1 News & Views 2 News & Views 3 2011 NBT Retrospective on APEX
  6. Lu P, Rangan A, Chan SY, Appling DR, Hoffman DW, Marcotte EM, Global metabolic changes following loss of a feedback loop reveal dynamic steady states of the yeast metabolome, Metab Eng, 9(1):8-20 (2007) PubMed Link PDF Supplemental File 1 Supplemental File 2 Supplemental File 3
  7. Hart GT, Lee I, Marcotte EM, A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality, BMC Bioinformatics, 8:236. (2007) PubMed Link PDF


  1. Hart GT, Ramani AK, Marcotte EM., How complete are current yeast and human protein-interaction networks?, Genome Biol., 7(11):120 (2006) PubMed Link PDF Additional Data File 1
  2. Prince JT, Marcotte EM, Chromatographic alignment of ESI-LC-MS proteomics datasets by ordered bijective interpolated warping, Anal. Chem., 78(17):6140-52 (2006) PubMed Link PDF
  3. Ramakrishnan SR, Mao R, Nakorchevskiy AA, Prince JT, Willard WS, Xu W, Marcotte EM, Miranker DP, A fast coarse filtering method for peptide identification by mass spectrometry, Bioinformatics, 22(12):1524-31 (2006) PubMed Link PDF
  4. Narayanaswamy R, Niu W, Scouras A, Hart GT, Davies J, Ellington AD, Iyer VR, Marcotte EM, Systematic profiling of cellular phenotypes with spotted cell microarrays reveals new pheromone response genes, Genome Biol., 7(1):R6 (2006) PubMed Link PDF Supplement Supplemental Table 1 Supplemental Table 2 Supplemental Table 3 Supplemental Table 4
  5. Lee I, Narayanaswamy R, Marcotte EM, Bioinformatic prediction of yeast gene function, Yeast Gene Analysis, Stansfield, I., ed., Elsevier Press: (2006) PubMed PDF
  6. Eisenberg D, Marcotte E, McLachlan AD, Pellegrini M, Bioinformatic challenges for the next decade(s), Philos Trans R Soc Lond B Biol Sci., 361(1467):525-7 (2006) PubMed Link PDF


  1. Levskaya A, Chevalier AA, Tabor JJ, Simpson ZB, Lavery LA, Levy M, Davidson EA, Scouras A, Ellington AD, Marcotte EM, Voigt CA, Synthetic biology: Engineering Escherichia coli to see light, Nature, 438(7067):441-2 (2005) PubMed Link PDF the Science Daily press release Nature 2005 Gallery "First Glimpse" Nature feature on the iGEM competition featuring a bacterial portrait UT press release New York Times feature
  2. Ramakrishnan SR, Mao R, Nakorchevskiy AA, Prince JT, Willard WS, Xu W, Marcotte EM, Miranker DP, A fast coarse filtering method for protein identification by mass spectrometry, University of Texas Dept. of Computer Sciences, Technical Report, TR-05-06: (2005) PubMed PDF
  3. Wang R, Prince JT, Marcotte EM, Mass spectrometry of the M. smegmatis proteome: Protein expression levels correlate with function, operons, and codon bias, Genome Res., 15(8):1118-26 (2005) PubMed Link PDF
  4. Ramani AK, Bunescu RC, Mooney RJ, Marcotte EM, Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome, Genome Biology, 6(5):R40 (2005) PubMed Link PDF
  5. Bunescu R, Ge R, Kate RJ, Marcotte EM, Mooney RJ, Ramani AK, Wong YW, Comparative experiments on learning information extractors for proteins and their interactions, Artif Intell Med., 33(2):139-55 (2005) PubMed Link PDF
  6. Ramani AK, Marcotte EM, Bunescu RC, Mooney RJ, Using biomedical literature mining to consolidate the set of known human protein-protein interactions, Intelligent Systems in Molecular Biology-ACL Workshop, : (2005) PubMed PDF
  7. Date SV, Marcotte EM, Protein function prediction using the Protein Link Explorer (PLEX), Bioinformatics, 21(10):2558-9 (2005) PubMed Link PDF Supplemental Web Site


  1. Lee I, Date SV, Adai AT, Marcotte EM, A probabilistic functional network of yeast genes, Science, 306(5701):1555-8 (2004) PubMed PDF Supplemental methods Supplemental README Supplemental File 1 Supplemental File 2 Supplemental File 3 Supplemental File 4 Supplemental File 5 (Files 4 & 5 require a VRML viewer)
  2. Baliga NS, Bonneau R, Facciotti MT, Pan M, Glusman G, Deutsch EW, Shannon P, Chiu Y, Weng RS, Gan RR, Hung P, Date SV, Marcotte E, Hood L, Ng WV, Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea, Genome Res., 14(11):2221-34 (2004) PubMed PDF
  3. Fraser AG, Marcotte EM, Development through the eyes of functional genomics, Curr Opin Genet Dev., 14(4):336-42 (2004) PubMed Link PDF
  4. Bork P, Jensen LJ, Von Mering C, Ramani AK, Lee I, Marcotte EM, Protein interaction networks from yeast to human, Curr Opin Struct Biol, 14(3):292-9 (2004) PubMed Link PDF
  5. Adai AT, Date SV, Wieland S, Marcotte EM, LGL: Creating a map of protein function with an algorithm for visualizing very large biological networks, J Mol Biol, 340(1):179-90 (2004) PubMed Link PDF Supplemental Web Site Sourceforge Site For more recent support of LGL, see the LGL guide by Claire McWhite and the latest updates from the Opte Project
  6. Fraser AG, Marcotte EM, A probabilistic view of gene function, Nature Genetics, 36(6):559-64 (2004) PubMed Link PDF
  7. Marcotte EM, Practical computational approaches to infer protein function, Biosilico, 2:24-29 (2004) PubMed PDF
  8. Prince JT, Carlson MW, Wang R, Lu P, Marcotte EM, The need for a public proteomics repository, Nature Biotechnology, 22(4):471-472 (2004) PubMed Link Supplemental Web Site
  9. Date SV, Marcotte EM, Response to McDermott and Samudrala: Enhanced functional information from predicted protein networks, TRENDS in Biotechnology, 22(2):62-63 (2004) PubMed Link PDF


  1. Dhillon IS, Marcotte EM, Roshan U, Diametrical clustering for identifying anti-correlated gene clusters, Bioinformatics, 19(13):1612-9 (2003) PubMed PDF
  2. Lu P, Nakorchevskiy A, Marcotte EM, Expression deconvolution: a reinterpretation of DNA microarray data reveals dynamic changes in cell populations, Proc Natl Acad Sci U S A, 100(18):10370-5 (2003) PubMed PDF Supplemental files (zipped folder containing executable .jar file, yeast test data and cell cycle basis vectors)
  3. Date SV, Marcotte EM, Discovery of uncharacterized cellular systems by genome-wide analysis of functional linkages, Nat Biotechnol., 21(9):1055-62 (2003) PubMed PDF Fig S1 Fig S2 Table S1
  4. Marcotte EM, Assembling a jigsaw puzzle with 20,000 parts, Genome Biol., 4(6):323 (2003) PubMed PDF
  5. Ramani AK, Marcotte EM, Exploiting the co-evolution of interacting proteins to discover interaction specificity, J Mol Biol., 327(1):273-84 (2003) PubMed PDF Supplemental Web Site
  6. Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, Butler J, Endrizzi M, Qui D, Ianakiev P, Bell-Pedersen D, Nelson MA, Werner-Washburne M, Selitrennikoff CP, Kinsey JA, Braun EL, Zelter A, Schulte U, Kothe GO, Jedd G, Mewes W, Staben C, Marcotte E, Greenberg D, Roy A, Foley K, Naylor J, Stange-Thomann N, Barrett R, Gnerre S, Kamal M, Kamvysselis M, Mauceli E, Bielke C, Rudd S, Frishman D, Krystofova S, Rasmussen C, Metzenberg RL, Perkins DD, Kroken S, Cogoni C, Macino G, Catcheside D, Li W, Pratt RJ, Osmani SA, DeSouza CP, Glass L, Orbach MJ, Berglund JA, Voelker R, Yarden O, Plamann M, Seiler S, Dunlap J, Radford A, Aramayo R, Natvig DO, Alex LA, Mannhaupt G, Ebbole DJ, Freitag M, Paulsen I, Sachs MS, Lander ES, Nusbaum C, Birren B, The genome sequence of the filamentous fungus Neurospora crassa, Nature, 422(6934):859-68 (2003) PubMed PDF
  7. Bunescu R, Ge R, Kate R, Mooney R, Wong Y, Marcotte E, Ramani A, Learning to extract proteins and their interactions from Medline abstracts, ICML Workshop, : (2003) PubMed PDF


  1. Mallick P, Marcotte EM, Making sense of proteomics: Using bioinformatics to discover a protein's structure, functions, and interactions, Proteins and Proteomics: A Laboratory Manual, Simpson RJ, ed., Cold Spring Harbor Press: (2002) PubMed
  2. Dhillon IS, Marcotte EM, Roshan U., Diametrical clustering for identifying anti-correlated gene clusters, The University of Texas at Austin, Department of Computer Sciences, Technical Report TR-02-49: (2002) PubMed PDF
  3. Marcotte EM, Predicting protein function and networks on genome-wide scale, Gene Regulation and Metabolism: Post-Genomic Computational Approaches, Collado-Vides J, Holfstadt R, eds., MIT press: (2002) PubMed PDF
  4. Verjovsky Marcotte CJ, Marcotte EM, Predicting functional linkages from gene fusions with confidence, Applied Bioinformatics, 1(2):1-8 (2002) PubMed PDF


  1. Marcotte EM, Date SV, Exploiting big biology: Integrating large-scale biological data for functional inference, Brief Bioinform, 2(4):363-74 (2001) PubMed PDF
  2. Marcotte EM, The path not taken, Nature Biotechnology, 19(7):626-7 (2001) PubMed PDF
  3. Marcotte EM, Measuring the dynamics of the proteome, Genome Research, 11(2):191-3 (2001) PubMed PDF
  4. Marcotte EM, Xenarios I, Eisenberg D, Mining literature for protein interactions, Bioinformatics, 17(4):359-63 (2001) PubMed PDF README 500_abstracts_with_PMID Discriminating_words_for_interactions Discriminating_words_for_interactions_edited score_abstracts Perl script
  5. Eisenberg D, Marcotte E, Pellegrini M, Thompson M, Xenarios I, Yeates T, From genome sequences to protein interactions, FASEB J, 15:A724-A724 (2001) PubMed
  6. Xenarios I, Fernandez E, Salwinski L, Duan XJ, Thompson MJ, Marcotte EM, Eisenberg D, DIP: the database of interacting proteins: 2001 update, Nucleic Acids Res, 29(1):239-41 (2001) PubMed PDF


  1. Eisenberg D, Marcotte EM, Xenarios I, Yeates TO, Protein function in the post-genomic era, Nature, 405(6788):823-6 (2000) PubMed Link PDF
  2. Marcotte EM, Xenarios I, van der Bliek A, Eisenberg D, Localizing proteins in the cell from their phylogenetic profiles, Proc Natl Acad Sci U S A., 97(22):12115-20 (2000) PubMed Link PDF
  3. Marcotte EM, Computational genetics: Finding function by non-homology methods, Curr Opin Struct Biol., 10(3):359-65 (2000) PubMed Link PDF
  4. Yang H, Fitz-Gibbon S, Marcotte EM, Tai JH, Hyman EC, Miller JH, Characterization of a thermostable DNA glycosylase specific for U/G and T/G mismatches from the hyperthermophilic archaeon Pyrobaculum aerophilum, J Bacteriol., 182(5):1272-9 (2000) PubMed Link PDF
  5. Thompson M, Marcotte E, Pellegrini M, Yeates T, Eisenberg D, Increasing the specificity of protein functional inference by the Rosetta Stone method, Currents in Computational Molecular Biology, Miyano S, Shamir R, Takagi T, eds., Universal Academy Press, Inc.: (2000) PubMed PDF
  6. Xenarios I, Rice DW, Salwinski L, Baron MK, Marcotte EM, Eisenberg D, DIP: the database of interacting proteins, Nucleic Acids Res., 28(1):289-91 (2000) PubMed Link PDF


  1. Marcotte EM, Pellegrini M, Thompson MJ, Yeates TO, Eisenberg D, A combined algorithm for genome-wide prediction of protein function, Nature, 402(6757):83-6 (1999) PubMed Link PDF See also Sali, A. Genomics: Functional links between proteins. Nature 402, 23-26 (1999), Boston Globe (Nov. 3, 1999), Los Angeles Times (Nov. 4, 1999).
  2. Marcotte EM, Pellegrini M, Ng HL, Rice DW, Yeates TO, Eisenberg D, Detecting protein function and protein-protein interactions from genome sequences, Science, 285(5428):751-3 (1999) PubMed Link PDF See also Doolittle, R. F. Do you dig my groove? Nature: Genetics 23, 6-8 (1999).
  3. Marcotte EM, Pellegrini M, Yeates TO, Eisenberg D, A census of protein repeats, J Mol Biol., 293(1):151-60 (1999) PubMed Link PDF
  4. Pellegrini M, Marcotte EM, Thompson MJ, Eisenberg D, Yeates TO, Assigning protein functions by comparative genome analysis: protein phylogenetic profiles, Proc Natl Acad Sci U S A, 96(8):4285-8 (1999) PubMed Link PDF
  5. Pellegrini M, Marcotte EM, Yeates TO, A fast algorithm for genome-wide analysis of proteins with repeated sequences, Proteins: Struct. Funct. Genet., 35(4):440-6 (1999) PubMed Link PDF


  1. Marcotte EM, Eisenberg D, Chicken prion tandem repeats form a stable, protease-resistant domain, Biochemistry, 38(2):667-76 (1998) PubMed Link PDF
  2. Cascio D, Goodwill K, Marcotte E, A look at the future of macromolecular structure determination, Rigaku J., 15:1-5 (1998) PubMed PDF
  3. Robertus JD, Monzingo AF, Marcotte EM, Hart PJ, Structural analysis shows five glycohydrolase families diverged from a common ancestor, J Exp Zool., 282(1-2):127-32 (1998) PubMed Link PDF

Pre - 1998

  1. Hollis T, Honda Y, Fukamizo T, Marcotte E, Day PJ, Robertus JD, Kinetic analysis of barley chitinase, Arch Biochem Biophys., 344(2):335-42 (1997) PubMed Link PDF
  2. Marcotte EM, Monzingo AF, Ernst SR, Brzezinski R, Robertus JD, X-ray structure of an anti-fungal chitosanase from Streptomyces N174, Nat Struct Biol., 3(2):155-62 (1996) PubMed PDF News & Views
  3. Monzingo AF, Marcotte EM, Hart PJ, Robertus JD, Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core, Nat Struct Biol, 3(2):133-40 (1996) PubMed PDF
  4. Robertus, J. D., Hart, P. J., Monzingo, A. F., Marcotte, E. & Hollis, T, The structure of chitinases and prospects for structure-Based drug design, Can. J. Bot., 73 (Suppl. 1):S1142-S1146 (1995) PubMed PDF
  5. Kim YJ, Francisco L, Chen GC, Marcotte E, Chan CS, Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation, J Cell Biol., 127(5):1381-94 (1994) PubMed Link PDF
  6. Marcotte E, Hart PJ, Boucher I, Brzezinski R, Robertus JD, Crystallization of a chitosanase from Streptomyces N174, J Mol Biol, 232(3):995-6 (1993) PubMed Link PDF


  1. Publication # WO 2021236716 A2 Methods, systems and kits for polypeptide processing and analysis. PCT filed May 19, 2021.
  2. Publication # WO 2021168083 A1 Peptide and protein c-terminus labeling. PCT filed Feb 18, 2021.
  3. Publication # WO 2020072907 A1 Solid-phase N-terminal peptide capture and release. PCT filed Oct 04, 2019.
  4. Publication # WO 2020037046 A1 Single molecule sequencing peptides bound to the major histocompatibility complex. PCT filed Aug 14, 2019. UK patent GB 2591384 B issued July 26, 2023. UK patent GB 2607829 B issued August 30, 2023.
  5. Publication # WO 2020023488 A1 Single molecule sequencing identification of post-translational modifications on proteins. PCT filed July 23, 2018.
  6. Publication # WO 2020014586 A1 Molecular neighborhood detection by oligonucleotides. PCT filed July 12, 2018.
  7. 10,175,249 B2, issued January 8, 2019. Proteomic identification of antibodies. Lavinder, Jason; Boutz, Danny; Wine, Yariv; Marcotte, Edward; Georgiou, George.
  8. 10,545,153 B2, issued January 28, 2020. Single molecule peptide sequencing. Publication # WO/2016/069124, Intl appl # PCT/US2015/050099, International filing date 15.09.2015. Marcotte, Edward; Anslyn, Eric; Ellington, Andrew; Swaminathan, Jagannath; Hernandez, Erik; Johnson, Amber; Boulgakov, Alexander; Bachman, Logan; Seifert, Helen. Improved single molecule sequencing. 11,162,952 B2, issued November 2, 2021. Canadian patent 2,961,493 issued October 3, 2023.
  9. 9,625,469, issued April, 18, 2017. Identifying peptides at the single molecule level. Marcotte, Edward; Swaminathan, Jagannath; Ellington, Andrew; Anslyn, Eric. Appl # 14128247, filed 22.06.2012; publication # US20140349860, 27.11.2014. UK patent GB2510499 issued April 8, 2020. 11,105,812 B2, issued August 31, 2021. Canadian patent CA 2,839,702 C issued April 20, 2021. US 11,435,358 B2, issued September 6, 2022. German patent DE 112012002570T5 issued August 10, 2023.
  10. Publication # WO 2013067308 A2, Compositions and methods for inducing disruption of blood vasculature and for reducing angiogenesis, PCT filed Nov 2, 2012; provisional patent # 61/555,212 filed Nov 3, 2011.
  11. Publication # WO 2013055867 A1, Genes involved in stress response in plants, PCT filed Oct 11, 2012.
  12. USPTO Application # 20120215458, Orthologous phenotypes and non-obvious human disease models, PCT filed July 13, 2010; provisional patent # 61/225,427 filed July 14, 2009.
  13. 9,146,241, issued September 29, 2015. Proteomic identification of antibodies. Lavinder, Jason; Wine, Yariv; Boutz, Danny; Marcotte, Edward; Georgiou, George. Appl # 13/684,395, filed November 23, 2012.
  14. 9,090,674 B2, issued July 28, 2015. Rapid isolation of monoclonal antibodies from animals. Reddy, Sai; Ge, Xin; Lavinder, Jason; Boutz, Danny; Ellington, Andrew D.; Marcotte, Edward M.; Georgiou, George.
  15. 6,892,139, issued May 10, 2005. Determining the functions and interactions of proteins by comparative analysis.
  16. 6,772,069, issued August 3, 2004. Determining protein function and interaction from genome analysis.
  17. 6,564,151, issued May 13, 2003. Assigning protein functions by comparative genome analysis protein phylogenetic profiles.
  18. 6,466,874, issued October 15, 2002. Rosetta stone method for detecting protein function and protein-protein interactions from genome sequences.